Logically speaking, it doesn't make sense to disperse the wolves. That would be like intentionally putting Covid positive people on planes. You'd want to isolate them to prevent the contagion from spreading- and if you still viewed them as a threat, annihilation would be the only option. Especially if there's a precedent for it already like you mentioned.
The biggest difference between werecurse and AIDS is that AIDS kills you, and werecurse turns you into a superhuman murdermachine. It wouldn't be ignored and disdained, it would be feared or exploited as a tool.
I imagine werewolves being kept as mercenaries or shock troops for human nations or any nation that can subdue them. Humans can get away with it by gaslighting and manipulating them into thinking they are heroes making a sacrifice for the sake of their friends and family.
Now, this is where your mafia comes in. Some of those wolves wouldn't be satisfied with the results of their sacrifice. After coming back from the fight, they are looked down on by civilians, treated like an unstable, deranged and literally poisonous existence. Either they band together, or they're collected by a manipulative sort and turned against the people who ostracized them.
How this goes depends on their leadership. It might take the same shape as the pride movement, or the civil rights movements. Or they might turn into a terrorist organization. Probably the most important thing you need to look for is heroes. Who the wolves consider heroes is going to be the most important part of their culture. Every wolf should have a list of specific names, and be able to detail a few of their legendary actions.
What those actions are will determine your wolves' culture. Even better if different individuals have different lists of names.
Now then. A lot of gay culture relies on secrecy. Throwing parties, introducing friends to one another without having to publicly risk yourself, dancing around the topic to avoid outing yourself to potentially hostile people. That is out of the question here. Anyone who sees the mask will know.
That means the wolves will have to go a different route. If you can't hide it, flaunt it. Perhaps they decorate their masks with South American ornaments, or wolf-shaped trimmings.
They would need clothing that allows the transformation to complete without being damaged, and that clothing would need to stand out even in wolf shape. South American clothing tends to be quite bright and highly decorated. Ponchos could be worn easily over a hulking monstrosity and still provide some modesty to a human form.
Something like this:
On the other hand, with enhanced senses, it might go the other way. They might avoid bright clothing or spicy foods since they offend their senses. Perhaps they wear dull, camouflaged clothing and only eat lightly seasoned foods. Or perhaps they can tolerate the pain and do it anyways, you never know. This is a good place to give your wolves individuality.
As for activities, aside from activisim, terrorism, or organized crime, I expect it depends on how easy it is for them to get together.
I mentioned parties already. They could gather and share food recipes, play 'Guess that smell', or just dance and sing like a normal party.
If they can't gather too openly, they might have a relay-type of event, where one person talks to another, and that person talks to another, and so on. Maybe they pass an item that has a certain person's scent on it, and they have to guess who it belongs to. Practically, that could be a security measure as well. 'This person' says you should be at King Street at 12.
Uh. I lost my train of thought. Hope something in all that is useful.