I'm sorry for you. But I also don't understand the meaning of 'tragedy' in your life story. Death? Well, everyone is on an existential journey toward death. Like it or not, we will all die. The only difference is whether we have an awareness of death or not. This is more of a spiritual experience than a tragedy.
Alternatively, we may have witnessed or will witness the death of those close to us. Going back to the first point, because we all die. This is a heartbreaking experience that almost everyone has experienced. I personally witnessed the funerals of two of my best friends (one I was able to attend, the other not due to COVID-19), and remembering it still feels heartbreaking.
Finally, this tragedy could be that you have a medical history that those close to you don't understand, like Kaori (Kimi no Uso). If this is the case, it's best to be honest with those closest to you. Check your health while you still have time. And spend more time with those you love, while strengthening your spiritual experience. This way, your life might be better.
Hope it helps you.
Regards.